This is a list of the Irish Recorded Music Association's Irish Singles Chart Top 50 number-ones of 2008.
| Issue Date | Song | Artist |
|---|---|---|
| 3 January | When You Believe | Leon Jackson |
| 10 January | Piece of Me | Britney Spears |
| 17 January | ||
| 24 January | Now You're Gone | Basshunter |
| 31 January | ||
| 7 February | ||
| 14 February | ||
| 21 February | ||
| 28 February | Mercy | Duffy |
| 6 March | The Ballad of Ronnie Drew | Various Artists |
| 13 March | ||
| 20 March | Mercy | Duffy |
| 27 March | Low | Flo Rida featuring T-Pain |
| 3 April | The Munster Song | Glen Keating & Greg Ryan |
| 10 April | The Galway Girl | Sharon Shannon & Mundy |
| 17 April | ||
| 24 April | ||
| 1 May | ||
| 8 May | ||
| 15 May | 4 Minutes | Madonna featuring Justin Timberlake |
| 22 May | Take A Bow | Rihanna |
| 29 May | ||
| 5 June | ||
| 12 June | ||
| 19 June | Forever | Chris Brown |
| 26 June | On Wings | Leanne Moore |
| 3 July | Forever | Chris Brown |
| 10 July | All I Ever Wanted | Basshunter |
| 17 July | ||
| 24 July | All Summer Long | Kid Rock |
| 31 July | ||
| 7 August | ||
| 14 August | ||
| 21 August | I Kissed a Girl | Katy Perry |
| 28 August | ||
| 4 September | ||
| 11 September | ||
| 18 September | Sex on Fire | Kings of Leon |
| 25 September | ||
| 2 October | So What | Pink |
| 9 October | ||
| 16 October | About You Now | The Saw Doctors |
| 23 October | So What | Pink |
| 30 October | Hero | The X Factor Finalists 2008 |
| 6 November | ||
| 13 November | ||
| 20 November | Run | Leona Lewis |
| 27 November | ||
| 4 December | ||
| 11 December | ||
| 18 December | Hallelujah | Alexandra Burke |
| 25 December |
|
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